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    Handbook of Statistics in Clinical Oncology (English Edition)

    Beschreibung Handbook of Statistics in Clinical Oncology (English Edition). Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts:Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents.Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs.Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials.Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added.Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.



    Buch Handbook of Statistics in Clinical Oncology (English Edition) PDF ePub

    Handbook of Statistics in Clinical Oncology / Taylor ~ Pharmacokinetics in Clinical Oncology: Statistical Issues. Statistics of Phase 0 Trials. CRM Trials for Assessing Toxicity and Efficacy. Seamless Phase I/II Trial Design for Assessing Toxicity and Efficacy for Targeted Agents. Overview of Phase II Clinical Trials. Designs Based on Toxicity and Response. Designs Using Time to Event Endpoints/Single Arm versus Randomized Phase II. Phase II .

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    Handbook of Statistics in Clinical Oncology, 2nd edition ~ Handbook of Statistics in Clinical Oncology, 2nd edition Edited by Crowley, J. and Ankerst, D. P. Daniel Sargent . Division of Biostatistics Mayo Clinic Rochester, Minnesota, U.S.A. Search for more papers by this author. Sumithra Mandrekar. Division of Biostatistics Mayo Clinic Rochester, Minnesota, U.S.A. Search for more papers by this author. Ann Oberg. Division of Biostatistics Mayo Clinic .

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    101577874 - NLM Catalog Result ~ Language: English ISBN: 9781439862001 (hardcover : alk. paper) LCCN: 2012001496 MeSH: Clinical Trials as Topic; Computational Biology; Data Interpretation, Statistical; Neoplasms/therapy*; Research Design*; Translational Medical Research Notes: "A Chapman & Hall book." Rev. ed. of: Handbook of statistics in clinical oncology / [edited by] John Crowley, Donna Pauler Ankerst. 2006. Includes .

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    Statistics in Oncology / Journal of Clinical Oncology ~ DOI: 10.1200/JCO.2008.18.5900 Journal of Clinical Oncology - published online before print September 21, 2016 . PMID: 18669450

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